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Tissue Transglutaminase (tTG) IgG

Ordering Recommendation

Recommended single screening test for IgA-deficient individuals with suspected celiac disease. (IgA testing recommended to identify IgA deficiency.)

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May aid in monitoring adherence to gluten-free diet in celiac disease confirmed patients.

Mnemonic
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Mon-Sat
Reported
1-2 Days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation:
Collect:
Serum separator tube (SST).
Specimen Preparation:
Remove serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to a Standard Transport Tube. (Min: 0.5 mL)
Storage/Transport Temperature:
Refrigerated
Unacceptable Conditions:
Refrigerated.
Remarks:
Plasma. Hemolyzed or severely lipemic specimens.
Stability:
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year
Reference Interval
5 U/mL or less
6-9 U/mL
Negative
Weak Positive
10 U/mL or greater
Positive
Interpretive Data
The tTG IgG assay may aid in the diagnosis of gluten-sensitivity enteropathy (i.e., celiac disease, dermatitis herpetiformis) in tTG IgA negative patients with confirmed IgA deficiency.  A negative tTG IgG test alone does not rule out gluten-sensitive enteropathy. 
Note
Human recombinant tTG antigen is utilized in this assay
CPT Code
86364
Components
Component Chart Name
Tissue Transglutaminase (tTG) Ab, IgA
Component Test Code
0056009
LOINC
56537-4
Aliases
Tissue Transglutaminase
Transglu
taminase
tTG

tTG IgG
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