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Serine Proteinase 3 (PR3) Antibody

Ordering Recommendation

When used in conjunction with other autoantibody tests (ANCA, MPO), may aid in differentiating suspected Wegener granulomatosis (WG) from other vasculitides. May be useful to monitor patients with PR3 antibodies.

Panel tests are available. For the workup of suspected vasculitis, refer to ANCA-Associated Vasculitis Profile (ANCA/MPO/PR3) (3003745). For patients with a history of vasculitis, refer to Myeloperoxidase (MPO) Antibody and Serine Proteinase 3 (PR3) Antibody with Reflex to Anti-Neutrophil Cytoplasmic Antibody, IgG by IFA (3003746).

Mnemonic
PR3
Performed
Mon-Sat
Methodology
Semi-Quantitative Multiplex Bead Assay
Reported
1-2 Days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation:
Collect:
Serum separator tube. 
Specimen Preparation:
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to a Standard Transport Tube. (Min: 0.2 mL)
Storage/Transport Temperature:
Refrigerated.
Unacceptable Conditions:
Plasma, urine, or other body fluids.  Contaminated, hemolyzed, or severely lipemic specimens., icteric, or lipemic specimens.
Remarks:
Stability:
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Reference Interval
19 AU/mL or less
Negative
20-25 AU/mL
26 AU/mL or greater
Equivocal
Positive
Interpretive Data
Approximately 85% of patients with a C-ANCA pattern by IFA have antibodies specific for PR3.
Compliance Category: FDA
Note
CPT Code
83516
Components
Component Chart Name
Serine Proteinase 3 (PR3) Ab, IgG
Component Test Code
0050527
LOINC
6968-2
Aliases
PR3
PR3 Ab
PR3 IgG Antibodies
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