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Glomerular Basement Membrane Antibody, IgG (IFA)
Ordering Recommendation
May be useful in detecting glomerular basement membrane (GBM) antibodies. Combined use of IFA Glomerular Basement Membrane Antibody, IgG by Multiplex Bead Assay and IFA (2008403) may improve diagnostic sensitivity for disease. If positive, may be useful for monitoring treatment response.
Mnemonic
GBM-G IFA
Performed
Mon-Sat
Methodology
Indirect Fluorescent Antibody
Reported
1-3 Days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation:
Collect:
Serum separator tube.
Specimen Preparation:
Separate serum from cells ASAP or within 2 hours of collection. Transport 1 mL serum. (Min: 0.5 mL)
Storage/Transport Temperature:
Refrigerated.
Unacceptable Conditions:
Remarks:
Stability:
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Reference Interval
Negative
Interpretive Data
When present, IgG antibody to glomerular basement membrane (GBM) antigen detected by either indirect fluorescent antibody (IFA) or multiplex bead assay helps support a diagnosis of Goodpasture syndrome. However, the combined result of both assays performed during initial evaluation improves the diagnostic sensitivity for disease. A positive result in one or both assays should be confirmed by renal biopsy.
This test was developed and its performance characteristics were determined by CDL. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Compliance Category: FDA
Note
CPT Code
86255
Components
Component Chart Name
GBM Antibody, IgG by IFA
Component Test Code
0049191
LOINC
29994-1
Aliases
Anti-GBM Antibody
Anti-Glomerular Basement Membrane Antibody
GBM IgG IFA
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