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Cyclic Citrullinated Peptide (CCP) Antibody, IgG

Ordering Recommendation

Highly specific serologic test that aids in the workup of suspected rheumatoid arthritis or undifferentiated inflammatory arthritides. Rheumatoid Arthritis Panel (3004055) is the preferred test.

Mnemonic
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Mon-Sat
Reported
Within 24 hours
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation:
Collect:
Serum separator tube (SST).
Specimen Preparation:
Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to a Standard Transport Tube. (Min: 0.3 mL)
Storage/Transport Temperature:
Refrigerated
Unacceptable Conditions:
Urine or plasma. Contaminated, hemolyzed, grossly icteric, heat-inactivated, or severely lipemic specimens.
Remarks:
Stability:
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Reference Interval
19 Units or less
20-39 Units
Negative
Weak Positive
40-59 Units
Moderate Positive
60 Units or Greater
Strong Positive
Interpretive Data
Anti-cyclic citrullinated peptide (anti-CCP), IgG antibodies are present in about 69-83 percent of patients with rheumatoid arthritis (RA) and have specificities of 93-95 percent. These autoantibodies may be present in the preclinical phase of disease, are associated with future RA development, and may predict radiographic joint destruction. Patients with weak positive results should be monitored and testing repeated.
Note
CPT Code
86200
Components
Component Chart Name
Cyclic Citrullinated Peptide Ab, IgG
Component Test Code
0055256
LOINC
33935-8
Aliases

ACPA Antibody

Anti Citrullinated Antibody

Anti CitrullineAnti-CCP

Anti-CCP Antibody

Anti-Citrullinated Ab

Anti-Citrullinated Antibody

Anti-Citrullinated Protein/Peptide Antibody (ACPA)

Anti-Citrulline Antibody

Anti-Cyclic Citrullinated Peptide

AntiCCP Antibody

Anticitrullinated Antibody

Anticitrullinated Protein/Peptide Antibody (ACPA)

Anticitrulline Antibody

Anticyclic Citrullinated Peptide (CCP) Antibody

CCP

CCP3 Antibody

Citrullinated Ab

Citrullinated Antibody

Citrullinated Protein/Peptide Antibody (ACPA)

Citrulline Antibody

Soft-CCP

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