Cyclic Citrullinated Peptide (CCP) Antibody, IgG

Ordering Recommendation

Highly specific serologic test that aids in the workup of suspected rheumatoid arthritis or undifferentiated inflammatory arthritides. Rheumatoid Arthritis Panel (3004055) is the preferred test.

Mnemonic

Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Mon-Sat

Reported

Within 24 hours

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation:

Collect:

Serum separator tube (SST).

Specimen Preparation:

Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to a Standard Transport Tube. (Min: 0.3 mL)

Storage/Transport Temperature:

Refrigerated

Unacceptable Conditions:

Urine or plasma. Contaminated, hemolyzed, grossly icteric, heat-inactivated, or severely lipemic specimens.

Remarks:

Stability:

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval

19 Units or less

20-39 Units

Negative

Weak Positive

40-59 Units

Moderate Positive

60 Units or Greater

Strong Positive

Interpretive Data

Anti-cyclic citrullinated peptide (anti-CCP), IgG antibodies are present in about 69-83 percent of patients with rheumatoid arthritis (RA) and have specificities of 93-95 percent. These autoantibodies may be present in the preclinical phase of disease, are associated with future RA development, and may predict radiographic joint destruction. Patients with weak positive results should be monitored and testing repeated.

Note

CPT Code

86200

Components

Component Chart Name

Cyclic Citrullinated Peptide Ab, IgG

Component Test Code

0055256

LOINC

33935-8

Aliases

ACPA Antibody

Anti Citrullinated Antibody

Anti CitrullineAnti-CCP

Anti-CCP Antibody

Anti-Citrullinated Ab

Anti-Citrullinated Antibody

Anti-Citrullinated Protein/Peptide Antibody (ACPA)

Anti-Citrulline Antibody

Anti-Cyclic Citrullinated Peptide

AntiCCP Antibody

Anticitrullinated Antibody

Anticitrullinated Protein/Peptide Antibody (ACPA)

Anticitrulline Antibody

Anticyclic Citrullinated Peptide (CCP) Antibody

CCP

CCP3 Antibody

Citrullinated Ab

Citrullinated Antibody

Citrullinated Protein/Peptide Antibody (ACPA)

Citrulline Antibody

Soft-CCP