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Cardiolipin Antibody, IgG

Ordering Recommendation

Acceptable initial test when antiphospholipid syndrome (APS) is strongly suspected. Order with Lupus Anticoagulant Reflexive Panel (0030181) and Beta-2 Glycoprotein 1 Antibodies, IgG and IgM (0050321). Cardiolipin Antibodies, IgG and IgM (0099344) is preferred.

Mnemonic
AC-IGG
Performed
Mon-Sat
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Reported
1-2 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation:
Collect:
Serum separator tube. 
Specimen Preparation:
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to a Standard Transport Tube. (Min: 0.3 mL)
Storage/Transport Temperature:
Refrigerated.
Unacceptable Conditions:
Plasma or other body fluids. Contaminated, heat-inactivated, hemolyzed, or lipemic specimens.
Remarks:
Stability:
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year
Reference Interval
<=14 GPL
Negative
15-19 GPL
Indeterminate
20-80 GPL

 
Low to Moderately Positive
81 GPL or above
High Positive
Interpretive Data
Anti-mitochondrial antibodies (AMA) are thought to be present in 90-95% of patients with primary biliary cholangitis (PBC). However, the frequency of detected antibodies may be cohort or assay dependent, as lower sensitivities have been reported. Not all PBC patients are positive for AMA; some patients may be positive for SP100 and/or GP210 antibodies. A negative result does not rule out PBC.
Compliance Category: FDA
Note
CPT Code
86381
Components
Component Chart Name
Cardiolipin Antibody IgG
Component Test Code
0050901
LOINC
3181-5
Aliases
ACA
aCL
aCL Antibody
aCL IgG
Anti-Cardiolipin
Anticardiolipin
Anticardiolipin Antibodies
Cardiolip
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